瓢虫防卫生物碱2-(12-氨基十三烷基)吡咯烷的合成
SYNTHESIS OF 2-(12-AMINOTRIDECYL)PYRROLIDINE, A NEW DEFENSIVE ALKALOID
-
摘要: 2- (12 -氨基十三烷基 )吡咯烷 (1)是从墨西哥大豆瓢虫 Epilachna varivestis中分离的新防卫生物碱。本文报道以 2 -吡咯烷甲醇和 11-溴 - 1-十一烷醇为起始原料合成该防卫生物碱 ,Wittig反应是实现本合成的关键步骤。
-
关键词:
- 防卫生物碱 /
- 2-(12-氨基十三烷基)吡咯烷 /
- 合成
Abstract: The efficient synthesis of 2 (12 aminotridecyl)pyrrolidine (1), a new defensive alkaloid of Mexican bean beetle, Epilachna varivestis(Coccinellidae), has been achieved by employing the Wittig reaction as key step and 1 bromo 11 ethylenedioxyundecane as precursor of phosphonium bromide. Commercially available 2 pyrrolidinemethanol and 11 bromo 1 undecanol were used as the starting materials.-
Key words:
- defensive alkaloid /
- 2-(12-aminotridecyl)pyrrolidine /
- synthesis
-
M cCo rm ick K. D. , A t tygalle A. B. , Xu S. 2C. et al, T etrahed ron, 1994, 50: 2365 A t tygalle A. B. , Xu S. 2C. , M cCo rm ick K. D. et al, T etrahed ron, 1993, 49: 9333 Takahata H. , Takehara H. , O hkubo N. et al, T etrahed ron: A symm etry , 1990, 1: 561 M a D. and L u X. , T etrahed ron, 1990, 46: 6139 Bestmann H. J. , Ko schatzky K. H. , SchatzkeW. et al, L iebig s A nn. Chem , 1981, 9: 1705 HallD. R. , Beevo r P. S. , L ester R. et al, Chem istry and Ind ustry , 1975, 5: 216 Ko K. 2Y. and Eliel E. L. , J. O rg. Chem , 1986, 51: 5353 B raconnierM. F. , B raekman J. C. and Daloze D. , B u ll. S oc. Ch im. B elg , 1985, 94: 605 M iyash itaM. , Sato H. and Yo sh iko sh iA. , T etrahed ron L ett. , 1992, 33: 2833 -
点击查看大图
计量
- 文章访问数: 1451
- HTML全文浏览量: 42
- PDF下载量: 464
- 被引次数: 0
下载:
