α-三联噻吩对淡色库蚊血细胞的光敏作用研究

刘扬; 丰俊; 吴计划; 黄青春

α-三联噻吩对淡色库蚊血细胞的光敏作用研究

1.
华东理工大学药学院生物反应器工程国家重点实验室,上海200237

基金项目:

国家重点基础研究发展计划项目(2003CB114400);国家自然科学基金项目(30400295);上海市教委重点学科建设基金.

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出版历程
- 收稿日期: 2007-09-14

Photosensitive Toxicity of α-Terthienyl on Hemocytesin Culex pipiens pallens Larvae

1.
State Key Laboratory of Bioreactor Engineering,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

摘要

摘要: 研究了α-三联噻吩(α-T)对淡色库蚊Culex pipiens pallens幼虫血细胞的光敏作用。结果表明,在活体和离体条件下,α-T对淡色库蚊4种主要血细胞的形态延展及增殖均有不同程度的影响,处理后较短的时间内,α-T能促进血细胞的增殖,但随着作用时间的延长,其对血细胞均表现出抑制作用,且抑制程度随α-T浓度升高而逐渐增强。α-T对淡色库蚊不同血细胞的影响具有一定的差异,在处理早期,其对浆血胞(SP)和原血胞(PR)的增殖促进作用较强,而在处理后期,其对粒血胞(GR)和珠血胞(SP)的抑制作用较强,并且改变了淡色库蚊幼虫体内不同血细胞之间的比例,使得GR和SP所占比例逐渐降低。实验还表明,α-T对各种离体血细胞增殖的促进作用均较对活体的弱,且促进时间明显缩短。
- α-三联噻吩 /
- 淡色库蚊 /
- 血细胞 /
- 光敏作用
Abstract: The photosensitive toxicity of α-terthienyl (α-T) on the hemocytes in Culex pipiens pallens larvae was under investigation. The results showed that α-T,in vivo and in vitro,obviously affected the morphological ductility and the proliferation of the four main hemocytes. α-T promoted the reproduction of hemocytes in a short time after processing,but then gradually inhibited the hemocytes. The inhibition enhanced as the concentration increased.Moreover,α-T showed different extent of photosensitive toxicity to the four hemocytes and strongly changed the proportion of the hemocytes.At the early period of processing,α-T promoted the reproduction of plasmalocyte and prohemocyte,while at the later period,α-T strongly decreased the proportion of granulocyte and spherulocytes.In addition,the promotion of α-T on the proliferation of the four hemocytes,in vitro,was significantly weaker than that in vivo,and lasted shorter time.
- α-terthienyl /
- Culex pipiens pallens /
- hemocytes /
- photosensitive toxicity

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文章访问数: 1348
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