阿维菌素脲醛树脂微胶囊的制备及其缓释性能

韩志任; 杜有辰; 李刚; 慕卫; 刘峰

阿维菌素脲醛树脂微胶囊的制备及其缓释性能

1.
山东农业大学植物保护学院,山东泰安 271018

基金项目:

国家"十一五"科技支撑计划(2006BAD08A03);山东省博士后科研择优资助项目(200603065).

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出版历程
- 收稿日期: 2007-09-14

Preparation and Sustained-release Behavior of Abamectin Urea-formaldehyde Resin Microcapsules

1.
College of Plant Protection,Shandong Agricultural University,Tai'an 271018,China

摘要

摘要: 以脲醛树脂为囊壁材料,采用原位聚合法制备了阿维菌素微胶囊。探讨了甲醛-尿素摩尔比(F/U)、溶剂、分散剂、消泡剂对微胶囊形态和粒径分布的影响,测定了阿维菌素微胶囊的释放特性。结果表明:当甲醛-尿素摩尔比为1.75,甲苯∶ 氯苯=3∶ 4为溶剂,分散剂亚甲基二萘磺酸钠质量分数为1.5％,有机硅消泡剂X-10C质量分数为0.7%时,能够制备出形态良好、平均粒径4.07 μm、包封率 98.89％,贮存稳定性良好的阿维菌素微胶囊;红外图谱分析表明,阿维菌素被包封于脲醛树脂囊壁内;释放规律符合一级动力学方程,阿维菌素微胶囊的t50是阿维菌素原药的3.4倍,说明阿维菌素微胶囊具有较好的缓释性能。
- 脲醛树脂 /
- 阿维菌素 /
- 微胶囊 /
- 形态 /
- 粒径分布 /
- 缓释性能
Abstract: Microcapsules containing abamectin were synthesized via the in-situ polymerization method using urea-formaldehyde(UF) as a wall material.The particles size range and the surface morphology of the microcapsule were analyzed with varying formaldehyde/urea (F/U) mole ratio,solvent and dispersant.The sustained-release characteristics of abamectin CS was also studied.The optimal conditions were as follows:The F/U mole ratio was 1.75,toluene and chlorobenzene at weight ratio of 3∶ 4,the dosage of dispersant NNO was 1.5％ ,the dosage of silicone defoamer X-10C was 0.7％.The microcapsules showed satisfied surface morphology and particle size distribution,with the mean particle diameter of 4.07 μm.The product displayed good stability and its encapsulation ratios were 98.89％.IR spectra showed that abamectin was contained in urea-formaldehyde wall.The profile could be described by the first order kinetics equation,the release t50 of AVM CS was about 3.4 times as much as AVM TC,AVM CS has obviously sustained effect.
- urea-formaldehyde resin /
- abamectin /
- microcapsules /
- surface morphology /
- particle size distribution /
- sustained-release characteristics

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参考文献(19)

GAO De-lin (高德霖) .微胶囊技术在农药剂型中的应用[J].Modern Chemical Industry(现代化工),2000,20(2):10-14.

MACCONNELL J G,DEMCHAK R J,PREISER F A,et al.Relativity Toxicity and Penetrability of Abamectin and its 8,9-Oxide[J].J Agric Food Chem,1989,37:1498-1501.

BLOOMR A,MATHESON I.Environmental Assessment of Avermectin by The US Food and Drug Administration[J].Vet Parasitd,1993,48(1- 4):281-294.

CAMPBELL W C.Ivermectin and Abamectin[M].New York:Springer-verlag,1989:60-123.

FU Ren-chun(付仁春),ZHOU Jing(周菁),YUAN Qing-mei(袁青梅),et al.制备脲醛树脂阿维菌素微胶囊的研究[J].Yunnan Chemical Technology(云南化工),2003,30(4):14-16.

ZHOU Jing(周菁),FU Ren-chun(付仁春),LONG Quan(隆泉),et al.阿维菌素微胶囊的制备工艺优化[J].J Yunnan Univ(Nat Sci)(云南大学学报,自然科学版),2003,25(6):511-514.

ZHOU Jing(周菁),CHEN Tao(陈韬),PU Jiang(溥江) ,et al.微胶囊缓释性能的对比研究[J].J Yuxi Teachers College(玉溪师范学院学报),2007,23(3): 68-70.

ZHOU Jing(周菁),WANG Xiao-yan(王晓艳),CHEN Tao(陈韬),et al.阿维菌素微胶囊制备工艺的研究[J].Yunnan Chem Tech(云南化工),2007,34(1):16-19.

ZHAO De(赵德),LIU Feng(刘峰),MU Wei (慕卫),et al.毒死蜱微囊悬浮剂的制备及微胶囊化条件的优化[J].Chin J Pestic Sci(农药学学报),2006,8(1):77-82.

ZHAO De(赵德),LIU Feng(刘峰),MU Wei (慕卫),et al.毒死蜱微胶囊制备中表面形态和包封率的影响因素[J].Chin J Appl Chem(应用化学),2007,24(5):589-592.

LI Zhu-zhu(李珠柱),WEN Li-xiong(文利雄),LIU Fan(刘凡),et al.新型阿维菌素纳米控释剂的制备及性能研究[J].Chin J Pestic Sci(农药学学报),2005,7(3):275-281.

LEE H Y,LEE S J,CHEONG I W,et al.Microencap-sulation of Fragrant Oil Via in Situ Polymerization:Effect of pH and Melamine-formaldehyde Molar Ratio [J].J Micro-encapsulation,2002,19 (5):559-569.

ZHAO Lin-wu(赵临五),WANG Chun-peng(王春鹏).Urea-formaldehyde Adhesive(脲醛树脂胶黏剂)[M].Beijing(北京):Chemical Industry Press (化学工业出版社),2005:9.

HIROYUKI KAGE,HIDEAKI KAWAHARA,NAOMICHI HANADA,et al.Operating Conditions and Microcapsules Generated by in Situ Polymerization [J].Advanced Power Technol,2002,13(3):265-285.

LUO Yan(罗艳),CHEN Shui-lin(陈水林),LU Da-nian(陆大年),et al.原位聚合法制备微胶囊过程中的ζ 电位[J].Textile Auxiliaries(印染助剂),2000,17(1):6-8.

WANG Hai-bo(王海波),LI Yan-mei(李艳梅),LIU De-shan(刘德山).分散体系形成中表面活性剂使用量的判据[J].Chem J Chinese Univ(高等学校化学学报),2004,(25):140-143.

LUO Yan(罗艳),CHEN Shui-lin(陈水林).分散染料微胶囊的制备及其结构性能的关系[J].Textile Auxiliaries(印染助剂),2002,19(5):7-10.

CHIH PONG CHANG,TAKAO YAMAOTO,MIHO KIMURA,et al.Release Characteristics of an Azo Dye from Poly (Ureaurethane) Microcapsules[J].Journal of Controlled Release,2003,86:207-211.

JEGAT C,TAVERDET J L.Stirring Speed Influence Study on the Microencapsulation Process and on the Drug Release from Microcapsules [J].Polymer Bulletin,2000,44: 345-351. (Ed.TANG J)

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