苯甲酰脲类化合物的合成及杀虫活性

张文文; 郑震; 彭延庆; 徐晓勇; 李忠

苯甲酰脲类化合物的合成及杀虫活性

1.
上海市化学生物学重点实验室,华东理工大学药学院,上海 200237

基金项目:

国家自然科学基金(20502006,2087203);上海市科委和教委资助项目(073919107,064319022,B507).

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出版历程
- 收稿日期: 2008-12-20

Synthesis and Insecticidal Activity of Benzoylphenylurea Derivatives

1.
Shanghai Key Lab of Chemical Biology,School of Pharmacy,East China Universityof Science and Technology,Shanghai 200237,China

摘要

摘要: 对2-氨基-5-芳基-1,3,4- 口恶二唑的合成进行了深入研究,找到了一种基于HBr-H2O2 体系的绿色合成新方法,并以此为中间体,合成了18个未见报道的苯甲酰脲类目标化合物,所有化合物均通过核磁共振、高分辨质谱、红外光谱的分析鉴定。生物活性测试结果表明,在500 mg/L浓度下该系列目标化合物均未表现出显著的杀虫活性。
- HBr-H₂O₂ 溴代体系 /
- 绿色合成 /
- 苯甲酰脲 /
- 昆虫生长调节剂
Abstract: A cleaner approach to 2-amino-5-aryl-1,3,4-oxadiazoles,a series of benzoylphenylurea intermediates were developed and optimized by using HBr-H2O2 system as an alternative to molecular bromine.Eighteen novel benzoylphenylurea compounds were synthesized starting from 2-amino-5-aryl-1,3,4-oxadiazoles,and were identified by 1H NMR,HRMS and IR spectra.However,no remarkable insecticidal activity was observed during bioassay.
- H₂O₂/HBr bromination system /
- green synthesis /
- benzoylurea /
- insect growth regulator

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参考文献(15)

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