吡啶衍生物研究(Ⅻ):2-丙酸酯的合成及除草活性

冉兆晋; 倪汉文; 段红霞; 李楠; 董燕红; 傅滨; 肖玉梅; 覃兆海

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吡啶衍生物研究(Ⅻ):2-丙酸酯的合成及除草活性

1.
中国农业大学理学院, 北京 100193
2.
中国农业大学农学与生物技术学院, 北京 100193

基金项目:

国家自然科学基金课题( 20472112) ; 国家"十五"科技攻关课题(2004BA308A22-1).

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- 收稿日期: 2008-12-08

Studies on Pyridine Derivatives (Ⅻ):Synthesis and Herbicidal Activity of 2(2-Aryloxypyridine-4-carbonyloxy) propionates

1.
College of Science,China Agricultural University,Beijing 100193,China
2.
College of Agriculture and Biotechnology,China Agricultural University,Beijing 100193,China

摘要

摘要: 以2-氯-4-氰基吡啶和酚类化合物为原料,通过醚化、水解、酯化等反应合成了一系列2-(2-芳氧基吡啶-4-甲酰氧基)丙酸酯类化合物,其结构通过1H NMR和MS分析确证。生物活性测定结果表明,在1 500 g/hm2剂量下,部分目标化合物对油菜、反枝苋和马唐表现出较强的除草活性,用药15 d内植物叶片逐渐失绿变黄,直至枯死,生长受到严重抑制。
- 二芳醚 /
- 吡啶衍生物 /
- 合成 /
- 除草活性
Abstract: A novel series of 2-(2-aryloxy pyridine-4-carbonyloxy)propionates were synthesized by etherification,hydrolysis and esterification starting from 2-chloroisonicotinonitrile and phenoles.All of the structures were comfirmed by 1H NMR and MS spectra.Preliminary bioassay showed that they were effective to Brassica campestris L.,Amaranthus retroflexus L.and Digitaria sanguinalis (Linn.) Scop.at 1 500 g/hm2.In 15 days of adminstration,the grasses lost their green sucessively and the growth was seriously inhibited.
- diaryl ether /
- pyridine derivatives /
- synthesis /
- herbicide activity

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参考文献(11)

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KLEEMANN A,BALTRUSCHAT H S.Herbicidal 2,6-Disubstituted Pyridines and 2,4-Disubstituted Pyrimidines: EP 0723960 .1996-07-31.

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SCOTTM S,ELISABETH A,SCHMITTLING E A,et al,Synthesis of Diaryl Ethers,Diaryl Thioether,and Diarylamine Mediated by Potassium Fluoride-Alumina and 18-Crown-6:Expansion of Scope and Utility [J].J Org Chem,1998,63:6338-6342.

SUN Ke(孙克),LV Liang-zhong(吕良忠),ZHAI Shu-de (翟树德),et al.乳氟禾草灵的化学合成[J].Agrochemicals (农药),1996,35:17-19.

MANN F G,TURNBULL J H.Xanthones and Thiaxanthones.Ⅲ.The Synthesis of 9-Oxa-1-azaanthrone(4-azaxanthone) [J].J Chem Soc,1951:761-762. (Ed.JIN S H)

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文章访问数: 1109
HTML全文浏览量: 29
PDF下载量: 328
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吡啶衍生物研究(Ⅻ):2-丙酸酯的合成及除草活性

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Studies on Pyridine Derivatives (Ⅻ):Synthesis and Herbicidal Activity of 2(2-Aryloxypyridine-4-carbonyloxy) propionates

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出版历程

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