N-苯基氨基邻苯二甲酰亚胺衍生物的合成及初步杀虫活性

柳明; 崔永亮; 王毅; 段又生; 芮昌辉; 王敏; 刘尚钟

N-苯基氨基邻苯二甲酰亚胺衍生物的合成及初步杀虫活性

1.
中国农业大学应用化学系,农业部农药化学与应用技术重点开放实验室,北京 100193
2.
中国农业科学院植物保护研究所,北京 100193

基金项目:

国家自然科学基金(20572129);国家"十一五"科技支撑计划(2006BAE01A01-11).

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出版历程
- 收稿日期: 2008-12-12

Synthesis and Preliminary Bioassay of N-Phenylaminophthalimide Derivatives

1.
Department of Applied Chemistry,China Agricultural University,Key Laboratory of Pesticide Chemistry and Application,Beijing 100193,China
2.
Institute of Plant Protection,China Academic of Agricultural Sciences,Beijing 100193,China

摘要

摘要: 为寻找新型环境友好型杀虫剂,用取代苯酐与取代苯肼在冰乙酸中缩合,合成了11个未见杀虫活性报道的N-苯基氨基邻苯二甲酰亚胺衍生物,其中7个是新化合物。所有化合物结构均通过核磁共振氢谱及液质联机(LC-MSD)确认,并利用X-ray单晶衍射确认了 A02 的晶体结构。初步的杀虫活性测试结果表明,大部分化合物对小菜蛾具有一定的杀虫活性,其中化合物 A06 在600 g/mL下96 h的致死率达到84％。
- N-苯基氨基邻苯二甲酰亚胺 /
- 合成 /
- 杀虫活性
Abstract: In order to discover novel environmental friendly insecticide,11 no insecticidal activity reported N-phenylaminophthalimide derivatives were synthesized through condensation reaction of substituted phthalic anhydride and substituted phenylhydrazine in glacial acetic acid,and 7 among them were new compounds.The structures of all compounds were confirmed with 1H NMR & LC-MSD,and the crystal structure of A02 was characterized by X-ray crystal diffraction method.The preliminary bioassay showed that some compounds had certain insecticidal activity against Plutella xylostella Linnaeus at 600 μg/mL,and the lethal rate of compound A06 was 84% after 96 hours.
- N-phenylaminophthalimide derivatives /
- synthesis /
- biological activity

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参考文献(17)

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