4-烃氧亚氨基己内酯的合成与杀菌活性

肖炎双; 闫晓静; 徐彦军; 袁会珠; 王道全; 梁晓梅

4-烃氧亚氨基己内酯的合成与杀菌活性

1.
农业部农药化学及应用重点开放实验室,中国农业大学应用化学系,北京 100193
2.
中国农业科学院植物保护研究所,北京 100193

基金项目:

国家科技支撑计划:农药创制工程(2006BAE01A02-11)资助.

计量
- 文章访问数: 1147
- HTML全文浏览量: 27
- PDF下载量: 343
- 被引次数: 0
出版历程
- 收稿日期: 2008-12-10

Synthesis and Fungicidal Activity of4-Alkyloxyiminohexanolactone Derivatives

1.
Key Laboratory of Pesticide Chemistry and Application,Department of Applied Chemistry,China Agricultural University,Beijing 100193,China
2.
Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China

摘要

摘要: 以1,4-环己二酮为原料,经氧化扩环,再与烃氧胺盐酸盐反应合成了10个未见文献报道的4-烃氧亚氨基己内酯( 6 ),其结构经1H NMR、元素分析或MS确证。初步的杀菌活性测定表明,部分目标化合物在50 μg/mL下对供试5种病原菌的生长有一定的抑制作用。
- 4-烃氧亚氨基己内酯 /
- 合成 /
- 杀菌活性
Abstract: Ten novel 4-alkyloxyiminohexanolactone derivatives were synthesized from cyclohexane-1,4-dione and their structures were confirmed by 1H NMR and elemental analysis or MS.Preliminary bioassay showed some of them exhibit certain fungicidal activity against five fungi tested.
- 4-alkyloxyiminohexanolactone /
- synthesis /
- fungicidal activity

HTML全文

参考文献(11)

WANG Xiao-ping(汪晓平),WANG Dao-quan(王道全),N-取代-α-氧代环十二烷基磺酰胺的合成及杀菌活性[J].Chem J Chinese Univ(高等学校化学学报),1997,18(6):889-893.

ZHU W J,WU P ,LIANG X M,et al.Design,Synthesis,and Fungicidal Activity of Macrolactones and Macrolactams with a Sulfonamide Side Chain[J].J Agric Food Chem,2008,56(15):6547-6553.

LI X H,YANG X L,LIANG X M,et al.Synthesis and Biological Activities of 2-Oxocycloalkylsulfon-amides[J].Bioorg Med Chem,2008,16:4538-4544.

LI Ming-lei,LIANG Xiao-mei,QIN Zhao-hai,et al.Synthesis and Fungicidal Activities of (E)-α-Oxocyclododecanone Oxime Ethers[J].Chin J Pestic Sci(农药学学报),2006,8 (3):209-213.(in English)

HUANG J X,JIA Y M,LIANG X M ,et al.Synthesis and Fungicidal Activity of Macrolactams and Macrolactones with an Oxime Ether Side Chain[J].J Agric Food Chem,2007,55:10857-10863.

FIESER L F,FIESER M.Regent for Organic Synthesis[M].John Wiley and Sons,Inc.,New York,1967:485-486.

KASZTREINER E,SZILAGYI G,KOSARY J,et al.Synthesis of O-Subsititued Hydroxylamines[J].Acta Chim Acade Sci Hung,1975,84(2):167-180.

LATERE J P,PHILIPPE L.2-Oxepane-1,5-dione:A Precursor of a Novel Class of Versatile Semicrystalline Biodegradable(Co)polyesters[J].Macromolecules,1986,19:1828-1838.

CHEN Nian-chun (陈年春).Bioassay of Pesticides (农药生物测定技术)[M].北京(Beijing):Beijing Agticultural University Press (北京农业大学出版社),1991.

ABELE E,ABELE R,RUBINA K,et al.Alkylation of Aryl and Hetaryl Ketoximes with Alkyl Iodides Prepared in Situ from Alkyl Chlorides under Phase Transfer Catalysis Conditions[J].Synth Comm,1998,28 (14):2621-2633.

OHTANI I,KUSUMI T,KASHMAN Y,et al.High-Field FT NMR Application of Mosher's Method.The Absolute Configuration of Marine Terpenoids[J].J Am Chem Soc,1991,113:4092-4096. (Ed.JIN S H)

施引文献

资源附件(0)

访问统计