甘氨酸法合成草甘膦中由甲醛引发的副反应研究

黄 明; 尹应武; 查正炯

甘氨酸法合成草甘膦中由甲醛引发的副反应研究

1.
西南大学化学化工学院,重庆 400715
2.
清华大学化学系, 北京 100084
3.
北京紫光英力化工技术有限公司, 北京 100085

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出版历程
- 收稿日期: 2009-11-11

Study of side-reaction on synthesis of glyphosate inducedby glycine method

1.
School of Chemistry and Chemistry Engineering, Southwest University, Chongqing 400715, China
2.
Department of Chemistry Tsinghua University, Beijing 100084, China
3.
Th-unis Insight Co. , Ltd. , Beijing 100085, China

摘要

摘要: 利用核磁共振碳谱、磷谱、氢谱对甘氨酸法合成草甘膦的各阶段反应进行定量跟踪分析, 发现由甲醛引起的副反应是影响草甘膦收率的重要因素之一,证实了羟甲基亚瞵酸、增甘膦、N-甲基草甘膦和亚磷酸是甘氨酸法合成草甘膦的主要副产物,减少或抑制其生成是草甘膦合成工艺优化的关键。探讨了抑制副反应发生的条件,对甘氨酸法合成草甘膦工艺优化有重要的理论指导意义。
- 草甘膦 /
- 机理 /
- 副反应 /
- 核磁共振
Abstract: It was found that the side-reactions caused by formaldehyde is an important influence factor in the synthesis of glyphosate started from glycine by analysis with 13C NMR, 31P NMR, and 1H NMR. Hydroxymethyl phosphonic acid, Polaris, N-(methylation)glyphosate and phosphite were the main by-products and reducing or restraining the generation of them is the crux of optimizing glyphosate technique. Optimizing the technique of synthesizing glyphosate starting from glycine has great significance in theory.
- glyphosate /
- mechanism /
- side-reaction /
- NMR

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参考文献(9)

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