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分子靶标烟草花叶病毒外壳蛋白的结构生物学研究进展

李向阳 陈卓 杨松 宋宝安

李向阳, 陈卓, 杨松, 宋宝安. 分子靶标烟草花叶病毒外壳蛋白的结构生物学研究进展[J]. 农药学学报, 2010, 12(4): 391-401.
引用本文: 李向阳, 陈卓, 杨松, 宋宝安. 分子靶标烟草花叶病毒外壳蛋白的结构生物学研究进展[J]. 农药学学报, 2010, 12(4): 391-401.
LI Xiang-yang, CHEN Zhuo, YANG Song, SONG Bao-an. Research progress of structure biology of tobacco mosaic virus coat protein as molecular targets[J]. Chinese Journal of Pesticide Science, 2010, 12(4): 391-401.
Citation: LI Xiang-yang, CHEN Zhuo, YANG Song, SONG Bao-an. Research progress of structure biology of tobacco mosaic virus coat protein as molecular targets[J]. Chinese Journal of Pesticide Science, 2010, 12(4): 391-401.

分子靶标烟草花叶病毒外壳蛋白的结构生物学研究进展

基金项目: 

国家重点基础研究发展计划(973计划)项目(2010CB126105);国家自然科学基金(20872021)资助项目.

Research progress of structure biology of tobacco mosaic virus coat protein as molecular targets

  • 摘要: 病毒外壳蛋白(CP)是烟草花叶病毒(TMV)基因结构的重要组成部分,其主要功能除保护核酸物质不被降解外,还与TMV的远距离移动及寄主症状有关。目前研究较多的是CP基因介导的抗性、药剂干扰CP的聚合等,而有关靶标CP与药剂的作用机理尚未有系统全面的报道。从结构生物学的角度出发,详细介绍了TMV CP在电镜及单晶衍射技术下的三维结构;比较了国内已报道的CP的基因序列;综述了CP在基因工程领域的应用及其受药剂分子的干扰作用等方面的研究进展。以毒氟磷药剂为例,分析了其可能作用于TMV CP的分子机理,预测了毒氟磷小分子与TMV CP大分子可能的作用位点。有助于进一步研究和发现新型抗TMV药剂。
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  • 收稿日期:  2010-05-20
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