手性农药毒性机制的对映体选择性

唐梦龄; 王丹; 傅柳松; 刘维屏

手性农药毒性机制的对映体选择性

1.
浙江大学环境与资源学院,杭州 310058

基金项目:

国家自然科学基金项目(20837002); 国家重点基础研究发展计划(973计划)(2009CB421603)课题.

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出版历程
- 收稿日期: 2011-01-04
- 修回日期: 2011-06-09

Enantioselectivity on toxic mechanisms of chiral pesticides

1.
College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China

摘要

摘要: 综述了手性农药在急性毒性、慢性毒性、细胞毒性、藻类与植物毒性及生物体富集方面的对映体选择性差异。大量研究显示,手性农药的不同对映异构体对于非靶标作用体的毒性存在显著差异,这种选择性差异既取决于手性农药的对映异构体,同时又与作用的受体相关。探讨了手性农药毒理学研究的重点和发展方向——在对映体水平上对手性农药的毒理机制进行全面深入的研究,对于评价农药对健康的风险及生产绿色高效的单一或复合的对映体农药具有指导意义。
- 手性农药 /
- 毒理 /
- 对映体选择性 /
- 综述
Abstract: The progress of chiral pesticide toxicology on the enantioselective level from the perspectives of chronic toxicity,acute toxicity,cytotoxicity,algae and plants,and the differences of bioaccumulation were reviewed.Many researches have shown that the toxicity of the enantiomers of chiral pesticides are significantly different to non-target receptor.These differences depend on the structure of the enantiomers and also the receptor.Discussing about the biological effects and toxicological mechanisms of chiral pesticides are meaningful to assess the health risk and to produce pure and enriched enantiomer of pesticides.
- chiral pesticide /
- toxicity /
- enantioselectivity /
- review

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参考文献(55)

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