昆虫对拟除虫菊酯类杀虫剂的代谢抗性机制研究进展

陈澄宇; 史雪岩; 髙希武

doi:10.16801/j.issn.1008-7303.2016.0078

昆虫对拟除虫菊酯类杀虫剂的代谢抗性机制研究进展

doi: 10.16801/j.issn.1008-7303.2016.0078

1.
中国农业大学植物保护学院, 北京 100193

基金项目:

公益性行业科技专项（201303027）.

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出版历程
- 收稿日期: 2016-07-19
- 修回日期: 2016-09-02
- 刊出日期: 2016-10-14

Mechanism of insect metabolic resistance to pyrethroid insecticides

1.
College of Plant Protection, China Agricultural University, Beijing 100193, China

摘要

摘要: 随着拟除虫菊酯类杀虫剂在卫生和农业害虫防治中的广泛应用，昆虫对此类杀虫剂产生抗性的报道越来越多。目前已明确昆虫对拟除虫菊酯类杀虫剂的抗性机制包括表皮穿透率下降、靶标抗性以及代谢抗性，其中代谢抗性机制较为普遍，而且其与昆虫对多种杀虫剂的交互抗性关系密切。目前，随着基因组、转录组以及蛋白质组学等新技术的发展及应用，昆虫对拟除虫菊酯类杀虫剂的代谢抗性机制研究也取得了很多新进展。昆虫体内细胞色素P450酶（P450s）、羧酸酯酶（CarE）及谷胱甘肽S-转移酶（GSTs）等重要解毒酶系的改变均与昆虫对拟除虫菊酯类杀虫剂的代谢抗性有关，其中这3类解毒酶的活性及相关基因表达量的变化是昆虫对此类杀虫剂产生代谢抗性的主要原因。明确昆虫对拟除虫菊酯类杀虫剂的代谢抗性机制，对合理使用此类杀虫剂及延缓抗药性的产生均具有重要意义。本文在总结拟除虫菊酯类杀虫剂代谢路径及相关生物酶研究概况的基础上，综述了近年来有关昆虫对此类杀虫剂代谢抗性机制研究的主要进展。
- 昆虫 /
- 拟除虫菊酯类杀虫剂 /
- 解毒酶 /
- 代谢抗性
Abstract: With indiscriminate use of pyrethroid insecticides on agricultural and urban settings insect pests, the pyrethroid resistance in insects has occurred widely. The resistance mechanisms of insects to pyrethroid insecticides include the resistance caused by the decline of insect cuticular penetration rate, insensitive target resistance and metabolic resistance. Among those mechanisms, the metabolic resistance of insects to pyrethroids is more commonly existed and closely related to insects cross resistance to a variety of insecticides. Recently, many new achievements on the mechanisms of insect metabolic resistance to pyrethroids insecticides have been obtained, with the application of new techniques such as proteomics, transcriptome and genomic techniques. The changes of insects insects are beneficial to rational use of pyrethroids insecticides and delay the development of insects resistance to pyrethroids. On the basis of summarizing the metabolic pathways of pyrethroids and the related metabolic enzymes, this article provides an overview of the new achievements on mechanisms of insect metabolic resistance to pyrethroid insecticides. detoxification enzymes such as cytochrome P450, carboxylesterase and glutathione S-transferase resulted in the metabolic resistance of insects to pyrethroid insecticide. Especially the changes of the activity and relative gene expression level of these detoxification enzymes are the main mechanisms of insects metabolic resistance to pyrethroids. Clarifying the metabolic resistance mechanisms of resistant insects are beneficial to rational use of pyrethroids insecticides and delay the development of insects resistance to pyrethroids. On the basis of summarizing the metabolic pathways of pyrethroids and the related metabolic enzymes, this article provides an overview of the new achievements on mechanisms of insect metabolic resistance to pyrethroid insecticides.
- insects /
- pyrethroid insecticides /
- detoxifying enzymes /
- metabolic resistance

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