Research progress on bioactivities and mechanism of aphid alarm pheromone (E)-β-farnesene and its analogues
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摘要: 蚜虫报警信息素 [(E)-β-farnesene，简称EBF] 是蚜虫腹管分泌的一种物质，它能对同种其他个体产生报警反应，使其迅速逃离危险现场。作为天然蚜虫信息素，EBF通过蚜虫嗅觉系统的气味结合蛋白OBPs和嗅觉受体ORs发挥作用，具有驱避、杀蚜、增效等多种生物活性，可用于蚜虫的行为调控，但由于其结构中存在的共轭双键而导致其稳定性差，从而限制了其实际应用。本文在简介蚜虫报警信息素EBF的基础上，系统介绍了EBF的结构修饰和改造进展，并对EBF及其类似物的生物活性和作用机制进行了综述，最后对EBF及其类似物的应用前景进行了展望，期望为开发具有实用价值的生态友好型蚜虫控制剂提供参考。
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关键词:
- 蚜虫报警信息素 /
- (E)-β-farnesene类似物 /
- 生物活性 /
- 作用机制 /
- 生态友好型蚜虫控制剂
Abstract: The aphid alarm pheromone, (E)-β-farnesene (EBF), is a natural product secreted from the aphid cornicle to warn other companions of danger. As a natural aphid pheromone, (E)-β-farnesene can interact with odorant binding proteins (OBPs) and olfactory receptor (ORs) in the aphid olfactory system. Because of its multiple biological activities such as repellent, aphicidal and synergistic effects, (E)-β-farnesene is regarded as an aphid behavior control agent. However, its application was a challenge due to its instability arising from the conjugated double bonds in EBF. A brief introduction of the current situation in aphid control was covered in this review. The discovery and activity of (E)-β-farnesene was also summaried. According to the recent results obtained in the studies of EBF analogues, the structure modification and optimization of (E)-β-farnesene, the activities of EBF analogues and their mode of action were reviewed. And the outlook on the trend of EBF analogues as candidates of eco-friendly aphicide is proposed. -
表 1 豌豆蚜基因组的气味结合蛋白[80]
Table 1. Odorant-binding proteins annotated in the Acyrthosiphon pisum genome[80]
基因名称
Name of geneEST 冗余
EST redundancy信号肽
Signal peptide氨基酸
Amino acids基因编号
Gene ID*ApisOBP1 112 1–21 aa 159 aa ACYPIG336037 ApisOBP2 29 1–19 aa 243 aa ACYPIG179180 ApisOBP3 52 1–23 aa 141 aa ACYPIG117886 ApisOBP4 22 1–22 aa 193 aa ACYPIG478320 ApisOBP5 21 1–25 aa 221 aa ACYPIG747500 ApisOBP6 3 1–19 aa 215 aa ACYPIG250873 ApisOBP7 7 1–30 aa 155 aa ACYPIG658982 ApisOBP8 2 1–18 aa 162 aa ACYPIG938564 ApisOBP9 3 1–24 aa 165 aa ACYPIG781430 ApisOBP10 ND 1–24 aa 143 aa ACYPIG102270 ApisOBP11 ND 1–23 aa 112 aa ACYPIG252504 ApisOBP12-CN ND No SP 112 aa ACYPIG244867 ApisOBP13-NT NA No SP 82 aa ACYPIG620194 ApisOBP14-CN NA NA 26 aa ACYPIG570521 ApisOBP15-NT NA No SP 23 aa ACYPIG803752 注：*蚜虫基因鉴定。CN：C端和N端都缺失；CT：C端缺失；NA：未申请；ND：未检测；NT：N端缺失；SP：信号肽。Note：*aphid gene identity. CN: both C- and N-terminus missing; CT: C-terminus missing; NA: not applied; ND: not detected; NT: N-terminus missing; SP: signal peptide. 
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