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氟吡呋喃酮及其类似物研究进展

苏彦豪 许磊川 赵宇 张倩 李益豪 王明安

苏彦豪, 许磊川, 赵宇, 张倩, 李益豪, 王明安. 氟吡呋喃酮及其类似物研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2022.0004
引用本文: 苏彦豪, 许磊川, 赵宇, 张倩, 李益豪, 王明安. 氟吡呋喃酮及其类似物研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2022.0004
SU Yanhao, XU Leichuan, ZHAO Yu, ZHANG Qian, LI Yihao, WANG Ming’an. Recent research progress on flupyradifurone and its analogues[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2022.0004
Citation: SU Yanhao, XU Leichuan, ZHAO Yu, ZHANG Qian, LI Yihao, WANG Ming’an. Recent research progress on flupyradifurone and its analogues[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2022.0004

氟吡呋喃酮及其类似物研究进展

doi: 10.16801/j.issn.1008-7303.2022.0004
基金项目: 国家自然科学基金 (21772229).
详细信息
    作者简介:

    苏彦豪,641526079@qq.com

    许磊川,xuleichuan@163.com

    通讯作者:

    王明安,wangma@cau.edu.cn

  • 中图分类号: TQ 453.2

Recent research progress on flupyradifurone and its analogues

Funds: the National Natural Science Foundation of China (21772229).
  • 摘要: 氟吡呋喃酮 (flupyradifurone) 是拜耳公司开发的新型丁烯内酯类杀虫剂,对刺吸式口器害虫具有优异的杀虫活性,与现有商品化新烟碱类杀虫剂相比,其作用机制独特,对蜜蜂低毒,自2014年上市以来就成为了农药学研究领域的热点。本文从氟吡呋喃酮的创制过程、生物活性及抗性、作用机制、代谢残留、对蜜蜂等非靶标生物的影响以及结构修饰等方面对该产品进行了综述。
  • 1  百部碱的分子结构

    1.  Molecular structure of stemofoline

    2  百部碱的优化和氟吡呋喃酮的发现[6,50]

    2.  The optimization of stemofoline and discovery of flupyradifurone[6,50]

    图  1  番茄植株不同部位施药后氟吡呋喃酮在植株体内的分布情况[6]

    Figure  1.  The distribution of flupyradifurone in different parts of the tomato plants after the application[6]

    图  2  IMD和FPF与CYP6CM1vQ分子对接模型[58]

    Figure  2.  Molecular docking mode of IMD and FPF within the CYP6CM1vQ[58]

    3  氟吡呋喃酮主要的代谢产物

    3.  The main metabolites of flupyradifurone

    4  化合物1-10的化学结构式 [129-131]

    4.  Chemical structures of compounds 1-10[129-131]

    5  化合物11-23的化学结构式[132-133]

    5.  Chemical structures of compounds 11-23[132-133]

    6  烷氧基丁烯内酯类化合物的设计思路[134]

    6.  Design strategy of the alkyloxy butenolide compounds[134]

    7  目标化合物的合成路线[135]

    7.  Synthetic route of the target compounds[135]

    8  化合物25-32的化学结构式[136-140]

    8.  Chemical structures of compounds 25-32[136-140]

    9  区域选择性C3-烷基化合成路线[141]

    9.  Synthetic route of the regioselective C3-alkylation[141]

    10  无催化剂的串联反应合成路线[142]

    10.  Synthetic route of catalyst-free tandem reactions[142]

    11  两类含取代苯乙烯基和丁烯内酯的氟吡呋喃酮结构类似物[143]

    11.  The two types of flupyradifurone analogues containing substituted styryl and butenolide[143]

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出版历程
  • 收稿日期:  2021-11-15
  • 录用日期:  2021-12-28
  • 网络出版日期:  2022-01-14

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