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琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展

毛玉帅 段亚冰 周明国

毛玉帅, 段亚冰, 周明国. 琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展[J]. 农药学学报, 2022, 24(5): 937-948. doi: 10.16801/j.issn.1008-7303.2022.0062
引用本文: 毛玉帅, 段亚冰, 周明国. 琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展[J]. 农药学学报, 2022, 24(5): 937-948. doi: 10.16801/j.issn.1008-7303.2022.0062
MAO Yushuai, DUAN Yabing, ZHOU Mingguo. Research progress of the resistance to succinate dehydrogenase inhibitors[J]. Chinese Journal of Pesticide Science, 2022, 24(5): 937-948. doi: 10.16801/j.issn.1008-7303.2022.0062
Citation: MAO Yushuai, DUAN Yabing, ZHOU Mingguo. Research progress of the resistance to succinate dehydrogenase inhibitors[J]. Chinese Journal of Pesticide Science, 2022, 24(5): 937-948. doi: 10.16801/j.issn.1008-7303.2022.0062

琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展

doi: 10.16801/j.issn.1008-7303.2022.0062
基金项目: 国家重点研发计划 (2016YFD0200500).
详细信息
    作者简介:

    毛玉帅,2020202064@njau.edu.cn

    通讯作者:

    周明国,mgzhou@njau.edu.cn

  • 中图分类号: TQ450.13;S481.4

Research progress of the resistance to succinate dehydrogenase inhibitors

Funds: the National Key Research and Development Program of China (2016YFD0200500)
  • 摘要: 作用于琥珀酸脱氢酶复合体的新型杀菌剂-琥珀酸脱氢酶抑制剂 (succinate dehydrogenase inhibitors, SDHIs) 已逐步成为继Qo位点呼吸抑制剂类 (QoIs) 和麦角甾醇生物合成抑制剂类(EBIs)杀菌剂之后的世界第3大类杀菌剂。近年来,SDHIs杀菌剂的市场占有份额逐年增加,新品种不断涌现,在植物病害化学防治中发挥着重要作用。然而,由于该类杀菌剂作用位点单一,抗药性已成为制约该类杀菌剂创制发展与科学应用的重要科学问题。本综述归纳了琥珀酸脱氢酶抑制剂类杀菌剂的开发、品种、抗性发生发展、抗性分子机制与应用现状,并结合作者研究团队的最新研究成果对其靶标生物学及应用技术研究进行了总结,以期为更高活性的SDHIs杀菌剂创制和应用提供参考。
  • 表  1  琥珀酸脱氢酶抑制剂类杀菌剂的化学结构分类

    Table  1.   Classification of the chemical structure of succinate dehydrogenase inhibitors fungicides

    化学结构
    Chemical structure
    中文名称
    Chinese name
    通用名
    Common name
    上市时间
    Announced date
    创制公司
    Registered company
    呋喃-酰胺
    furan-carboxamides
    甲呋酰胺 fenfuram 1974 壳牌和安万特 (现拜尔)
    Shell and Aventis (Bayer today)
    N-环丙基-N-苯甲基-吡唑-酰胺
    N-cyclopropyl-N-benzyl-pyrazole-carboxamides
    / isoflucypram 2019 拜尔 Bayer
    N-甲氧基-(苯乙基)-吡唑-酰胺
    N-methoxy-(phenyl-ethyl)-pyrazole-carboxamides
    氟唑菌酰羟胺 pydiflumetofen 2018 先正达 Syngenta
    氧硫杂环己二烯-酰胺
    oxathiin-carboxamides
    萎锈灵 carboxin 1966 尤尼罗亚尔 (现科聚亚) Uniroyal (Chemtura today)
    氧化萎锈灵 oxycarboxin 1973 尤尼罗亚尔 (现科聚亚) Uniroyal (Chemtura today)
    苯基-甲酰胺
    phenyl-benzamides
    麦锈灵 benodanil 1986 巴斯夫 BASF
    氟酰胺 flutolanil 1986 日本农药 Nihon Nohyaku
    灭锈胺 mepronil 1981 日本组合化学
    Kumiai chemical
    苯基-环丁基-吡啶酰胺
    phenyl-cyclobutyl-pyridineamide
    / cyclobutrifluram 2021 先正达 Syngenta
    苯基-含氧乙基-噻吩酰胺
    phenyl-oxo-ethyl-thiopheneamide
    异丙噻菌胺 isofetamid 2015 日本石原 Ishihara Sangyo Kaisha
    吡唑-4-酰胺
    pyrazole-4-carboxamides
    苯并烯氟菌唑 benzovindiflupyr 2012 先正达 Syngenta
    联苯吡菌胺 bixafen 2011 拜耳 Bayer
    氟茚唑菌胺 fluindapyr 2020 意赛格和富美实 Isagro and FMC Corporation
    氟唑菌酰胺 fluxapyroxad 2011 巴斯夫 BASF
    呋吡菌胺 furametpyr 1996 住友化学 Sumitomo Chemical
    / inpyrfluxam 2020 住友化学 Sumitomo Chemical
    吡唑萘菌胺 isopyrazam 2010 先正达 Syngenta
    氟唑菌苯胺 penflufen 2012 拜尔 Bayer
    吡噻菌胺 penthiopyrad 2008 三井化学 Mitsui Chemicals
    氟唑环菌胺 sedaxane 2011 先正达 Syngenta
    吡啶-酰胺
    pyridine-carboxamides
    啶酰菌胺 boscalid 2003 巴斯夫 BASF
    吡啶基-乙基-苯甲酰胺
    pyridinyl-ethyl-benzamides
    氟吡菌酰胺 fluopyram 2012 拜耳 Bayer
    吡嗪-酰胺
    pyrazine-carboxamides
    联苯吡嗪菌胺 pyraziflumid 2018 日本农药 Nihon Nohyaku
    噻唑-酰胺
    thiazole-carboxamides
    噻呋酰胺 thifluzamide 1997 日产化学 Nissan Chemical
    苯基噻唑-酰胺
    phenylthiazole-carboxamide
    拌种灵 amicarthiazol 1970 尤尼罗亚尔 (现科聚亚) Uniroyal (Chemtura today)
    注:“ / ”代表当前该药剂尚无对应中文名。Note: "/" means that there is no corresponding Chinese name for the fungicide at present.
    下载: 导出CSV

    表  2  SDHIs杀菌剂在中国的病害登记情况

    Table  2.   Disease registration of SDHIs fungicides in China

    杀菌剂名称 
    Fungicide 
    登记病害 
    Registered disease 
    杀菌剂名称
    Fungicide
    登记病害  
    Registered disease  
    杀菌剂名称
    Fungicide
    登记病害  
    Registered disease  
    氟酰胺
    flutolanil
    水稻纹枯病
    Rice sheath blight
    异丙噻菌胺
    isofetamid
    黄瓜灰霉病
    Cucumber gray mold
    噻呋酰胺
    thifluzamide
    水稻纹枯病
    Rice sheath blight
    花生白绢病
    Peanut stem rot
    番茄灰霉病
    Tomato gray mold
    小麦纹枯病
    Wheat sheath blight
    草坪褐斑病
    Lawn brown spot
    草莓灰霉病
    Strawberry gray mold
    花生白绢病
    Peanut stem rot
    灭锈胺
    mepronil
    棉花立枯病*
    Cotton blight
    黄瓜白粉病
    Cucumber powdery mildew
    荞麦纹枯病
    Buckwheat sheath blight
    黄瓜立枯病*
    Cucumber blight
    氟吡菌酰胺
    fluopyram
    番茄根结线虫
    Tomato root-knot nematode
    小麦锈病
    Wheat rust
    水稻纹枯病*
    Rice sheath blight
    香蕉根结线虫
    Banana root-knot nematode
    马铃薯黑痣病
    Potato black scurf
    吡噻菌胺
    penthiopyrad
    番茄灰霉病
    Tomato gray mold
    烟草根结线虫
    Tobacco root-knot nematode
    茭白纹枯病
    Water bamboo sheath blight
    葡萄灰霉病
    Grape gray mold
    黄瓜根结线虫
    Cucumber root-knot nematode
    水稻稻曲病
    Rice false smut
    黄瓜白粉病
    Cucumber powdery mildew
    黄瓜白粉病
    Cucumber powdery mildew
    花生锈病
    Peanut Rust
    氟唑环菌胺
    sedaxane
    玉米丝黑穗病
    Corn head smut
    西瓜根结线虫
    Watermelon root knot nematode
    啶酰菌胺
    boscalid
    马铃薯早疫病
    Potato early blight
    玉米黑粉病
    Corn smut
    萎锈灵
    carboxin
    小麦锈病
    Wheat Rust
    葡萄灰霉病
    Grape gray mold
    氟唑菌酰羟胺
    pydiflumetofen
    小麦赤霉病
    Fusarium head blight
    棉花黄萎病*
    Cotton verticillium wilt
    番茄早疫病
    Tomato early blight
    油菜菌核病
    Sclerotinia stem rot
    谷子黑穗病*
    Millet smut
    黄瓜灰霉病
    Cucumber gray mold
    草坪币斑病
    Lawn leaf spot
    麦类黑穗病*
    Wheat smut
    番茄灰霉病
    Tomato gray mold
    氟唑菌苯胺
    penflufen
    马铃薯黑痣病
    Potato black scurf
    高粱黑穗病*
    Sorghum smut
    草莓灰霉病
    Strawberry gray mold
    玉米丝黑穗病
    Corn head smut
    麦类锈病*
    Wheat rust
    苦瓜灰霉病
    Balsam pear gray mold
    小麦纹枯病
    Wheat sheath blight
    玉米丝黑穗病*
    Corn head smut
    番茄早疫病
    Tomato early blight
    水稻恶苗病*
    Rice bakanae disease
    氟唑菌酰胺
    fluxapyroxad
    水稻纹枯病
    Rice sheath blight
    油菜菌核病
    Sclerotinia stem rot
    注:“ * ”表示曾被登记防治,现今已过登记有效期。Note: " * " indicates that it has been registered for prevention and control, and now the validity period of registration has expired.
    下载: 导出CSV

    表  3  植物病原菌与SDHIs杀菌剂抗性相关的点突变基因型

    Table  3.   Genotypes of plant pathogenic bacteria related to SDHIs fungicide resistance

    报道的寄主  
    Hosts  
    病害病原物  
    Pathogens  
    涉及药剂  
    Fungicides  
    来源 
    Origin 
    突变位点  
    Mutation sites  
    小麦 Wheat 亚洲镰刀菌
    Fusarium asiaticum
    氟唑菌酰羟胺pydiflumetofen
    实验室[29]
    Laboratory
    B-H248Y, C1a-A64V, C1a-R67K
    禾谷镰刀菌
    Fusarium graminearum
    氟唑菌酰羟胺pydiflumetofen
    田间[24]
    Field
    C1a-A78V
    立枯丝核菌
    Rhizoctonia solani
    噻呋酰胺 thifluzamide 实验室[30]
    Laboratory
    B-H246Y, C-H139Y, D-H116Y
    小麦壳针孢菌
    Zymoseptoria tritici
    萎锈灵 carboxin 实验室[31-34]
    Laboratory
    B-N225I, B-H267Y/R/L, B-I269V, C-T79N, C-A84V,
    C-N86K, C-G90R, D-H129E, C-H152R
    小麦壳针孢菌
    Zymoseptoria tritici
    SDHIs 田间[23, 35-36]
    Field
    B-N225I, B-R265P, B-T268I/A, C-T79N/I, C-W80S,
    C-N86S/A, C-R151S/T/M, C-V166M, C-T168R, D-I50F,
    D-M114V, D-D129G
    大麦 Barley 核腔菌
    Pyrenophora teres
    SDHIs
    田间[23, 37]
    Field
    B-H277Y, C-N75S, C-G79R, C-H134R, C-S135R,
    D-D124N/E, D-H134R, D-D145G
    柱隔孢菌
    Ramularia collo-cygni

    SDHIs
    田间[23]
    Field
    B-N224T, B-T267I, C-N87S, C-G91R, C-H146R/L,
    C-H153R, C-G171D
    油菜 Oilseed rape 核盘菌
    Sclerotinia sclerotiorum
    啶酰菌胺 boscalid 实验室[38]
    Laboratory
    B-P226L
    核盘菌
    Sclerotinia sclerotiorum
    SDHIs
    田间[23]
    Field
    B-H273Y, C-G91R, C-H146R, C-G150R, D-T108K,
    D-H132R
    葫芦 Gourd 泻根亚隔孢壳
    Didymella bryoniae
    氟吡菌酰胺fluopyram 田间[39]
    Field
    B-H277R/Y
    叉丝单囊壳白粉菌
    Podosphaera xanthii
    SDHIs
    田间[23]
    Field
    B-H243Y
    葫芦、黄瓜
    Gourd, cucumber
    多主棒孢
    Corynespora cassiicola
    啶酰菌胺 boscalid
    田间[40-42]
    Field
    B-H278Y/R, B-I280V, C-S73P/L, C-N75S, C-H134R,
    D-S89P, D-95E, D-G109V
    番茄、草莓、苹果
    Tomato, strawberry, apple
    灰葡萄孢菌
    Botrytis cinerea
    SDHIs 田间[23, 43-46]
    Field
    B-P225L/T/F, B-N230I, B-H272Y/R/L/V, C-G85A&I93V&M158V&V168I, C-G37S, C-I93V,
    C-I79V&G85A&L151I, D-H132R
    花生 Peanut 米曲霉菌
    Aspergillus oryzae
    萎锈灵 carboxin 实验室[47]
    Laboratory
    B-H249Y/L/N, C-T90I, D-D124E
    百合 Lily 椭圆葡萄孢菌
    Botrytis elliptica
    SDHIs 田间[23]
    Field
    B-H272Y/R
    玉米 Corn 玉蜀黍黑粉菌
    Ustilago maydis
    萎锈灵 carboxin 实验室[48-49]
    Laboratory
    B-H257L
    开心果 Pistachio 链格孢菌
    Alternaria alternata
    SDHIs 田间[18]
    Field
    B-H277Y/R, C-H134R, D-D123E, D-H133R
    葡萄 Grape 葡萄钩丝壳菌
    Erysiphe necator
    SDHIs 田间[23]
    Field
    B-H242R, B-I244V, C-G169D/S
    芦笋 Asparagus 泡状匍柄霉菌
    Stemphylium vesicarium
    SDHIs 田间[23]
    Field
    B-P225L, H272Y/R
    马铃薯 Potato 茄链格孢菌,链格孢菌
    A. solani, A. alternata
    SDHIs 田间[23]
    Field
    B-H278R/Y, C-H134R/Q, D-D123E, D-H133R
    苹果 Apple 苹果黑星菌
    Venturia inaequalis
    SDHIs 田间[23]
    Field
    B-T253I, C-H151R
    a:由于小麦赤霉病菌种存在两个SDHC亚基基因,以C1,C2区分。a: Due to the existence of two SDHC subunit genes in the genus of wheat scab, they are distinguished by C1 and C2.
    下载: 导出CSV
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  • 收稿日期:  2021-11-16
  • 录用日期:  2022-06-24
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  • 刊出日期:  2022-10-10

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