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农药纳米乳剂研究进展

张航航 陈慧萍 曹冲 赵鹏跃 李凤敏 黄啟良 曹立冬

张航航, 陈慧萍, 曹冲, 赵鹏跃, 李凤敏, 黄啟良, 曹立冬. 农药纳米乳剂研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2022.0091
引用本文: 张航航, 陈慧萍, 曹冲, 赵鹏跃, 李凤敏, 黄啟良, 曹立冬. 农药纳米乳剂研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2022.0091
ZHANG Hanghang, CHEN Huiping, CAO Chong, ZHAO Pengyue, LI Fengmin, HUANG Qiliang, CAO Lidong. Research progress of nanoemulsion of pesticides[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2022.0091
Citation: ZHANG Hanghang, CHEN Huiping, CAO Chong, ZHAO Pengyue, LI Fengmin, HUANG Qiliang, CAO Lidong. Research progress of nanoemulsion of pesticides[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2022.0091

农药纳米乳剂研究进展

doi: 10.16801/j.issn.1008-7303.2022.0091
基金项目: 国家重点研发计划(2019YFD1002103)和中央级公益性科研院所基本科研业务费(Y2020XK14).
详细信息
    作者简介:

    张航航,1920353577@qq.com

    通讯作者:

    曹立冬,caolidong@caas.cn

  • 中图分类号: TQ450.6

Research progress of nanoemulsion of pesticides

Funds: Supported by the National Key Research and Development Program (2019YFD1002103); Central Public-Interest Scientific Institution Basal Research Fund(Y2020XK14)
  • 摘要: 近年来,纳米技术的迅猛发展为现代植物保护开辟了新的应用前景。纳米乳剂作为一种新型纳米载药系统,具有较好的分散性和润湿性、粒径小以及缓释增效等优点,从而提高农药在靶标表面的附着、沉积和渗透,并有效提高农药利用率,减少农药使用量,降低环境风险。本文介绍了纳米乳剂的组成成分以及制备方法,综述了纳米乳剂在农药领域的研究及其应用进展,同时对目前有较大争议的关于纳米乳剂和微乳剂的界限进行了讨论,并对该领域发展前景进行了展望,可为制备性能优异的纳米乳剂提供参考。
  • 图  1  不同类型纳米乳剂的结构

    Figure  1.  Structure of different types of nanoemulsion

    图  2  高效氯氟氰菊酯/醇酸树脂(LC/AR)纳米乳剂的制备示意图[43]

    Figure  2.  Schematic diagram of the preparation of lambda-cyhalothrin/alkyd (LC/AR) resin nanoemulsion[43]

    图  3  不同乳化剂制备的吡丙醚纳米乳剂在显微镜下的照片[44]

    Figure  3.  Microscope photos of pyripropylene ether nanoemulsion prepared with different emulsifiers under a microscope[44]

    图  4  β-氯氰菊酯(A和C)和载β-氯氰菊酯(B和D)纳米乳剂的透射电镜图[29]

    Figure  4.  TEM images of the β-CP free(A and C) and β-CP loaded (B and D) nanoemulsions[29]

    图  5  乳化剂前体的合成工艺方法[49]

    Figure  5.  Synthetic procedure of emulsifier precursor[49]

    图  6  百里香酚纳米乳剂的假设模型。皂苷的亲水部分由葡萄糖醛酸、半乳糖、木糖、鼠李糖和聚焦糖组成,皂苷的疏水部分朝向内部的百里香酚分子。葡萄糖醛酸的羧酸基(-COO)在百里香酚纳米乳剂中主要在表面提供负电荷[58]

    Figure  6.  Hypothetical model of the thymol nanoemulsion. The hydrophilic part of the saponin consists of glucuronic acid, galactose, xylose, rhamnose, and focused sugar, and the hydrophobic part of the saponin faces towards the inner thymol molecule. The carboxylic acid group (-COO) of glucuronic acid mainly provides a negative charge mainly on the surface in thymol nanoemulsion[58]

    图  7  百里香酚纳米乳剂在40kx (a)与80kx (b)下的Cryo-FESEM图[58]

    Figure  7.  Cryo-FESEM images of thymol nanoemulsion at 40 kx (a) and 80 kx (b) magnification[58]

    图  8  壳聚糖/柠檬醛纳米乳剂的制备示意图 [62]

    Figure  8.  Schematic diagram of the preparation of a chitosan/citral nanoemulsion [62].

    表  1  纳米乳剂在农药上的应用实例

    Table  1.   Examples of the application of nanoemulsion on pesticides

    类别
    Type
    农药
    Pesticide
    表面活性剂   
    Surfactant   
    最佳制备条件  
    Optimal preparation conditions  
    平均粒径
    Average particle size/nm
    研究亮点
    Research highlights
    参考文献
    Reference
    杀虫剂
    Insecticides
    蓖麻油
    Castor oil
    Tween-80, Span-20 超声乳化法
    Ultrasonic emulsification method
    114 具有长期稳定性;药效提高
    Long-term stability; Improved efficacy
    [40]
    氯菊酯
    Permethrin
    Tween-80 超声乳化法
    Ultrasonic emulsification method
    12.4 ± 1.13 药效提高;对非靶标生物安全性高
    Improved efficacy; Safe for non-target organisms
    [41]
    桉树油
    Eucalyptus oil
    Tween-80 低能乳化法
    Low-energy emulsification method
    77 延长桉树油的保质期;平均液滴尺寸显著降低;药效显著增高
    Extend the shelf life of eucalyptus oil; Decrease the average droplet size significantly; Increase the efficacy significantly
    [42]
    高效氯氟氰菊酯/醇酸树脂
    Lambda Cyhalothrin/Alkyd
    Montanov 82 原位反相乳化法
    Situ phase inverse emulsification
    50-150 优异的控制释放特性;纳米乳液在叶面上有更强的黏附性
    Excellent controlled release characteristics; Stronger adhesion on the leaf surface
    [43]
    吡丙醚
    Pyriproxyfen
    EL-20
    低能磁力搅拌法
    Low energy magnetic stirring method
    防效更持久,且药效提高;对蚯蚓低急性毒性和环境友好性;有更低的细胞凋亡率
    Durable control efficacy and improved efficacy; Low acute toxicity to earthworms and environmental friendliness; Lower apoptosis rate
    [44]
    β-氯氰菊酯β-cypermethrin APG + C12E3 高剪切搅拌乳化法
    High-shear stirring emulsification
    method
    113.5 在整个稀释过程中保持单相和均匀;在疏水表面具有良好的润湿和扩散性能。
    Maintain single phase and uniformity throughout the dilution process; Good wetting and diffusion properties on the hydrophobic surface
    [29]
    非水溶性农药 (如阿维菌素等)
    Insoluble pesticides (e.g. avermectin, etc.)
    / 先制备聚氨酯预聚体,进行加碱中和、加水相反转、第一减压蒸馏处理、乳化处理和第二减压蒸馏处理制备纳米乳剂。
    Firstly, the polyurethane prepolymer was prepared, and the nanoemulsion was prepared by alkali neutralization, water inversion, the first vacuum distillation treatment, emulsification treatment and the second vacuum distillation treatment.
    20-300 良好的分散性、稳定性和叶面附着性;具有缓控释性能,活性长;载体可生物降解,绿色环保、安全高效
    Good dispersion, stability, and adhesion on leaf surface; Slow and controlled release performance and long activity; Biodegradable, green, safe, and efficient carrier
    [45]
    醇酸树脂/非水溶性农药
    Alkyd resin/ insoluble pesticide
    SDBS + TX-10 相反转和减压蒸馏处理
    Reverse conversion and vacuum distillation
    30-250 良好的分散性、稳定性和叶面附着性;具有缓控释性能,活性长;载体可生物降解,绿色环保、安全高效
    Good dispersion, stability and leaf surface adhesion; With slow and controlled release performance and long activity; Biodegradable, green, safe and efficient carrier
    [46]
    杀虫剂
    Insecticides
    野生薄荷油Peppermint Tween-80 高能超声乳化法
    High-energy ultrasonication method
    11.98 具有长期稳定性;对棉蚜具有较高的触杀毒性
    Long-term stability; High contact toxicity against cotton aphid
    [47]
    阿维菌素Avermectin EL-40 低能乳化法
    Low-energy emulsification method
    92 良好的润湿性和扩散性;杀虫活性提高;对树状突细胞毒性较低
    Good wettability and diffusivity; Increased insecticidal activity; Less toxic to dendritic cells
    [48]
    阿维菌素Avermectin 阿维菌素乳化剂前体Avermectin emulsifier precursor 先制备乳化剂前体,进一步制备出纳米乳剂
    First, the precursor of the emulsifier was prepared, and then the nanoemulsion was prepared.
    小于100 药效提高;耐光解、低表面张力和高的叶面亲和性;具缓释性能
    Improved efficacy; Photolysis resistance, low surface tension and high leaf affinity; Slow release property
    [49]
    塔斯马尼亚蓝胶精油
    Tasmanian blue
    gum essential oil
    阿拉伯胶 + Tween-80/Span80
    Gum Arabic + Tween-80/Span80
    两段均质法
    Two-stage homogenization
    9.4和12.5 药效提高,稳定性提高
    Improved efficacy and stability
    [50]
    大蒜精油
    Garlic essential oil
    Tween-80 超声乳化法
    Ultrasonic emulsification method
    93.4 较高的杀螨活性;对大鼠等哺乳动物安全性高
    High acaricidal activity; Safe for rats and other mammals
    [51]
    联苯菊酯Bifenthrin NP-6 + NP-1 相转变法
    Phase inversion method
    25-30 润湿性、乳化性好、稳定性高
    Good wettability, emulsifiability and stability
    [52]
    杀菌剂
    Fungicides
    丁香酚、香芹酚和桂皮醛
    Cinnamaldehyde, Eugenol and Carvacrol
    Tween-80 高压微射流制备
    High pressure microfludizer method
    164.53 ± 8.70 纳米乳剂涂膜可潜在降低柑橘果实腐烂率、失重率和呼吸速率;抑菌效果显著;提高柑橘采后贮藏质量
    Reduce potentially the decay rate, weight loss rate and respiration rate of citrus fruits for nanoemulsion coating; Obvious bacteriostatic effect; Improve the storage quality of Citrus after harvest
    [53]
    三氟咪啶酰胺和氟吡菌酰胺Trifluoromidinamide and Fluoropylazamide 硬脂酸钾和甲基葡萄糖苷倍半硬酯酸酯
    Potassium stearate and methyl glucoside sesquistearate
    高压均质法结合纳米粒子包埋技术
    High-pressure homogenization method combined with nanoparticle entrapment technology
    115-124 稳定性好,能达到长效缓释的效果;对线虫防治明显增效
    Good stability and long-term sustained release effect; Obvious control effect on nematode
    [54]
    印楝油和香茅油
    Neem and Citronella oils
    Tween-20 自发乳化法
    Spontaneous emulsification
    method
    11.23±3.86-17.80±4.52与8.12±2.80-12.04±3.74 对水稻纹枯病菌和白绢病菌具有较强的抗真菌活性
    Strong antifungal activity against Rhizoctonia solani and Sclerotium rolfsii
    [55]
    丁香酚和长星花提取物
    Eugenol and Kitolod extract
    Span-85 + Tween-80 高能乳化法
    High-energy method
    288.7±9.2 纳米乳剂稳定,且抗菌活性强
    Stable and strong antibacterial activity
    [56]
    杀菌剂
    Fungicides
    木霉膜质
    Trichogenic-Lipid
    Tween-80 超声乳化法
    Ultrasonic emulsification method
    5-51 木霉膜质纳米乳剂种子引发显著自我保护和提高早期防御基因的表达水平
    Membrane lipid nanoemulsion seeds elicit significant self-protection and increase the expression level of early defense genes
    [57]
    百里香酚
    Thymol
    天然皂苷
    Quillaja saponin,
    超声乳化法
    Ultrasonic emulsification method
    274±2 百里酚纳米乳剂具有显著的抗菌作用、病害控制和植物生长促进活性,并能稳定3个月
    Thymol nanoemulsion has a significant antibacterial effect, disease control, and plant growth-promoting activity, and can be stable for 3 months
    [58]
    肉桂精油
    Cinnamon essential oil
    Tween-80 超声乳化法
    Ultrasonic emulsification method
    65.98 良好的稳定性和更好的抗真菌活性
    Good stability and better antifungal activity
    [59]
    薄荷油
    Peppermint oil
    Tween-80 高能超声法
    High-energy ultrasonication method
    小于100 对番茄早疫病的防治效果优异
    Excellent control effect on early blight caused by Alternaria solani
    [60]
    大蒜油
    Garlic oil
    Tween-80 + Span-80 超声乳化法
    Ultrasonic emulsification method
    52.27 提高对柑橘青霉的抑菌活性
    Improve the antibacterial activity against Penicillium italicum
    [61]
    壳聚糖/柠檬醛
    Chitosan/Citral
    Tween-80 高能超声法
    High-energy ultrasonication method
    27.0 抗菌活性增高
    Increased antibacterial activity
    [62]
    丁香酚
    Eugenol oil
    Tween-20 高能超声法
    High-energy ultrasonication method
    80 对棉花枯萎病菌有明显的抑制作用
    Obvious inhibitory effect on Fusarium
    oxysporum f. sp. vasinfectum
    [63]
    除草剂
    Herbicides
    草甘膦异丙胺盐
    Glyphosate
    isopropylamine
    短链烷基聚糖苷与有机硅
    SAPGs and organosilicone
    低能乳化法
    Low-energy emulsification method
    小于200 增强药物在给药系统中的渗透性,提高生物活性
    Enhance the permeability of drugs in the drug delivery system and improve the biological activity
    [64]
    银胶菊粗提取物
    Parthenium hysterophorus
    Crude extract
    Tensiofix + Tween-80 高能乳化法
    High-energy method
    140.10 稳定性良好,除草活性增强
    Good stability and enhanced herbicidal activity
    [65]
    野生型百里香精油、栽培型百里香精油以及马乔莲精油
    Wild and cultivated thyme
    and marjoram essential oils
    聚乙二醇二油酸酯与
    Toximol Polyethylene glycol dioleate and Toximol
    多次涡旋和超声处理制备
    Preparation by multiple vortex and ultrasonic treatment
    12.0, 22.4, 5.3 对田旋花表现出较强的除草活性
    Strong herbicidal activity against Convolvulus arvensis
    [66]
    其他
    Others
    甲基纤维素
    Methyl cellulose
    Tween-80 高压均质法
    High pressure
    homogenization method
    157.5 纳米乳剂包衣种子具有较高的吸胀率、出苗速度、发芽和活力指数
    Nanoemulsion-coated seeds have a higher imbibition rate, seedling emergence rate, germination, and vitality index
    [67]
    下载: 导出CSV
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  • 收稿日期:  2022-05-24
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