新型2,4-二苯基-1,3-噁唑啉类杀螨剂的研究进展

李永强; 于秀玲; 刘玉秀; 汪清民

doi:10.3969/j.issn.1008-7303.2014.06.01

新型2,4-二苯基-1,3-噁唑啉类杀螨剂的研究进展

doi: 10.3969/j.issn.1008-7303.2014.06.01

1.
南开大学元素有机化学国家重点实验室元素有机化学研究所天津化学化工协同创新中心, 天津 300071

基金项目:

“十二五”国家科技支撑计划项目(2011BAE06B08).

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出版历程
- 收稿日期: 2014-08-26
- 修回日期: 2014-11-03
- 刊出日期: 2014-12-12

Progress in the studies on 2,4-diphenyl-1,3-oxazoline acaricide

1.
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China

摘要

摘要: 乙螨唑是日本八州化学工业株式会社于20世纪80年代中期发现并于1998年商品化的惟一的2,4-二苯基-1,3-噁啉类新型杀螨剂,其通过抑制在哺乳动物和高级植物中没有而只存在于昆虫表皮和真菌细胞壁的几丁质的合成,可高选择性地防治害虫和害螨,具有高效、低毒和对非靶标生物安全的特性,符合当今绿色杀虫剂的要求和目标。本文概述了该类杀螨剂的先导发现、结构修饰及构效关系以及作用机制的研究进展,旨在为设计新颖、高效、低毒、绿色的2,4-二苯基-1,3-噁啉类杀虫、杀螨活性分子提供参考。
- 2,4-二苯基-1,3-噁啉 /
- 杀螨剂 /
- 结构修饰 /
- 构效关系 /
- 作用机制
Abstract: Etoxazole, discovered by Yashima Chemical Industry Co. Ltd. and launched in 1998, is the only commercialized acaricide of 2,4-diphenyl-1,3-oxazolines. It has unique mechanism of inhibition on chitin biosynthesis that only exists in insect cuticle and fungal cell wall but is absence in mammals and higher plants. Therefore, it possesses high efficiency, low toxicity, and safety for non-target organisms. These advantages accord with the requirement of the green pesticide. In this review, the discovery of leading product, structural modification, structure-activity relationships, and the action mechanism of etoxazole analogues, are summarized comprehensively. It is expected to provide fundamental support for the development of novel acaricidal/insecticidal compounds.
- 2,4-diphenyl-1,3-oxazoline /
- acaricide /
- structural modification /
- structure-activity relationship /
- action mechanism

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参考文献(32)

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